Entry level USP 4 system to change pH, maintain sink conditions and collect fractions
Adapted to a great variety of dosage forms
Temperature monitoring, accurate flow rate by valveless ceramic piston pump, filter saturation detection
The open loop system set-up is historically the one used to guarantee sink conditions (from 2 to 5 times inferior to saturation concentration) to test poorly soluble compounds. The open loop is also well adapted to ER, MR, SR dosage forms due to its media selection ability which allows a pH change on the fly.